<?php

$data = <<< DATA
data
data
#comment
;comment
data ;comment
data #comment
DATA;

echo preg_replace(
	'/
	    [;#]    # find strings starting with ; or #
	    .*      # and everything following that
	    $       # until it ends in a newline
	/mx',       // make it span multilies
	'',
    $data
);

data
data


data 
data